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[http://en.wikipedia.org/wiki/James_Lancaster Captain James Lancaster] was appointed "General" of the fleet and sailed in the [http://en.wikipedia.org/wiki/Red_Dragon_(1595) 'Red Dragon']. John Middleton was 'Vice-Admiral'. Other ships were in command of the [http://www.eicships.info/ships/shipdetail.asp?sid=111 57 'SusanHector'], . Other ships were the [http://www.eicships.info/ships/shipdetail.asp?sid=57 111 'HectorSusan']commanded by John Hayward, the [http://www.eicships.info/ships/shipdetail.asp?sid=9 'Ascension'] commanded by William Brand and the [http://www.eicships.info/ships/shipdetail.asp?sid=1483 'Guest']. The fleet captured a Portuguese vessel off the coast of Guinea and took her cargo of wine, oil and meal. After calling at [http://en.wikipedia.org/wiki/Saldanha_Bay Saldanha] at the Cape of Good Hope, Madagascar and Nicobar, they reached [http://en.wikipedia.org/wiki/Aceh Achin] on the northern tip of Sumatra where they were able to secure a cargo of pepper, cinamon and spices. The 'Susan' went to [http://en.wikipedia.org/wiki/Pariaman Priaman] on the coast of Sumatra where she obtained a cargo and sailed for home. Lancaster sent the 'Ascension' back with despatches and proceeded to [http://en.wikipedia.org/wiki/Bantam_(city) Bantam] where he was able to establish a [http://en.wikipedia.org/wiki/Factory_(trading_post) factory]. He the sent a pinnace to trade in the [http://en.wikipedia.org/wiki/Moluccas Moluccas] while he turned for home. An account of the voyage is given in [http://wwwbooks.google.archiveco.orguk/stream/lettersreceivedb01eastbooks?id=tCwwAAAAYAAJ&pg=PA107&dq=the+period+of+this+voyage+being+estimated+for+twenty+months&hl=en&ei=_D3tTI2nBdC2hAf-_eXMDA&sa=X&oi=book_result&ct=result&resnum=1&ved=0CCYQ6AEwAA#page/n27/mode/2up Letters received by v=onepage&q=the East India Company %20period%20of%20this%20voyage%20being%20estimated%20for%20twenty%20months&f=false A general history and collection of voyages and travels Vol I 8 page 107] (1602-13Google Books)].

Captain Henry Middleton, who had sailed on the first voyage with his brother John, led the expedition in the 'Red Dragon' again with the 'Hector', 'Ascension', and 'Susan'. Arriving at Bantam, the 'Hector' and 'Susan' loaded pepper and set out for home but [http://www.wrecksite.eu/wreck.aspx?139266 'Susan' was lost] on the way. The 'Red Dragon' and 'Ascension' proceeded to Amboyna hoping to establish a factory. They were unable to do so however due to opposition from the Dutch. The 'Ascension' then went to Banda while Middleton took the 'Red Dragon' to [http://en.wikipedia.org/wiki/Ternate Ternate] and [http://en.wikipedia.org/wiki/Tidore Tidore] where trading was permitted and a cargo of pepper obtained. He called at [http://en.wikipedia.org/wiki/Makian Makian] but Dutch objections prevented him from establishing a factory at Ternate though he obtained some cloves. The' Red Dragon' and 'Ascension' set sail for home but became separated en route. Middleton found the 'Hector' at Saldanha and the two ships arrived in England at the same time with 'Ascension' following later. The profit on first two voyages was reported as 95% on the capital. An account of the voyage is given in [http://wwwbooks.archivegoogle.orgco.uk/stream/lettersreceivedb01eastbooks?id=tCwwAAAAYAAJ&pg=PA191&dq=the+period+of+this+voyage+being+estimated+for+twenty+months&hl=en&ei=_D3tTI2nBdC2hAf-_eXMDA&sa=X&oi=book_result&ct=result&resnum=1&ved=0CCYQ6AEwAA#page/n29/mode/2up Letters received by v=onepage&q=the East India Company %20period%20of%20this%20voyage%20being%20estimated%20for%20twenty%20months&f=false A general history and collection of voyages and travels Vol I 8 page 191] (1602-13Google Books)].